It was during my neurology internship in Paris and after a Master degree in neuroscience that I discovered neuropathology. I was trained at the Pitié-Salpêtrière Hospital, where the neuropathology department interacts on a daily basis with a large number of structures specialized in the diagnosis and treatment of nervous system diseases as well as in research on their mechanisms. After a stay in the United States in Boston (Harvard Medical School) and New-York (Albert Einstein College of Medicine), I followed the steps of a hospital-university career pursuing, after my PhD, research activities more particularly oriented towards inflammatory and infectious diseases of the central nervous system (multiple sclerosis, encephalitis, Creutzfeldt-Jakob disease) and towards motor neuron diseases (amyotrophic lateral sclerosis). I am now part of the team "ALS : Causes and mechanisms of motor neuron degeneration" of the Paris Brain Institute (ICM - Inserm U1127 - CNRS - Sorbonne University). Since 2009 I am a University Professor - Hospital Practitioner (PUPH) at APHP-Sorbonne University. Since 2018, I am the head of the Neuropathology Department at the Pitié-Salpêtrière Hospital and I am the scientific director of Neuro-CEB.